4ev0

From Proteopedia

Crystal Structure of Thermus thermophilus Catabolite Activator Protein

Structural highlights

4ev0 is a 2 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.402Å
Ligands:	CMP, MG, SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CRP_THET8 Activates transcription. Positively regulates six promoters upstream of the TTHB186, TTHB147, TTHB178, TTHB159, TTHA0771 and TTHA0176 genes in a cAMP-dependent manner. Regulated genes include clustered regularly interspaced short palindromic repeat (CRISPR) associated (Cas) genes, and the genes encoding a putative transcriptional regulator, a protein containing the exonuclease III-like domain of DNA polymerase, a GCN5-related acetyltransferase homolog, and some T.thermophilus-specific proteins of unknown function. The consensus DNA-binding site of this transcriptional regulator is 5'-(CT)NNG(G/T)(G/T)C(A/C)N(A/T)NNTCACAN(G/C)(G/C)-3' in which N is G, A, T or C.^[1]

References

↑ Shinkai A, Kira S, Nakagawa N, Kashihara A, Kuramitsu S, Yokoyama S. Transcription activation mediated by a cyclic AMP receptor protein from Thermus thermophilus HB8. J Bacteriol. 2007 May;189(10):3891-901. doi: 10.1128/JB.01739-06. Epub 2007 Mar, 16. PMID:17369302 doi:http://dx.doi.org/10.1128/JB.01739-06

1 Structural highlights
2 Function
3 References

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PDB ID 4ev0

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4ev0

From Proteopedia

Crystal Structure of Thermus thermophilus Catabolite Activator Protein

Structural highlights

Function

References

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