Structural highlights
Function
1433_GIAIC Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Binds with varying affinity to various synthetic phosphopeptides having a consensus binding motif RSX(pS/pT)XP, called mode-1, where X is any residue and pS/pT is a phosphorylated serine/threonine, and to synthetic phosphopeptides having a consensus binding motif Xp(S/T)X1-2-COOH, called mode-3, in which the phosphorylated residue occupies the penultimate C-terminal position in the target protein, but does not bind to their unphosphorylated counterparts (PubMed:19733174). Binds to synthetic human RAF1 phosphopeptides, but not to their unphosphorylated forms. Binds to difopein, a polypeptide containing a phosphorylation-independent binding motif (PubMed:16368691, PubMed:19733174). Involved in encystation (PubMed:19733174). Involved in cell proliferation. Required for actin and tubulin cytoskeletal organization. Regulates actin filament formation and nuclear size (PubMed:28932813).[UniProtKB:P62261][1] [2] [3]
See Also
References
- ↑ Lalle M, Salzano AM, Crescenzi M, Pozio E. The Giardia duodenalis 14-3-3 protein is post-translationally modified by phosphorylation and polyglycylation of the C-terminal tail. J Biol Chem. 2006 Feb 24;281(8):5137-48. doi: 10.1074/jbc.M509673200. Epub 2005, Dec 20. PMID:16368691 doi:http://dx.doi.org/10.1074/jbc.M509673200
- ↑ Lalle M, Bavassano C, Fratini F, Cecchetti S, Boisguerin P, Crescenzi M, Pozio E. Involvement of 14-3-3 protein post-translational modifications in Giardia duodenalis encystation. Int J Parasitol. 2010 Feb;40(2):201-13. doi: 10.1016/j.ijpara.2009.07.010. Epub, 2009 Sep 3. PMID:19733174 doi:http://dx.doi.org/10.1016/j.ijpara.2009.07.010
- ↑ Krtkova J, Xu J, Lalle M, Steele-Ogus M, Alas GCM, Sept D, Paredez AR. 14-3-3 Regulates Actin Filament Formation in the Deep-Branching Eukaryote Giardia lamblia. mSphere. 2017 Sep 13;2(5). pii: mSphere00248-17. doi: 10.1128/mSphere.00248-17., eCollection 2017 Sep-Oct. PMID:28932813 doi:http://dx.doi.org/10.1128/mSphere.00248-17