4fwd

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Crystal structure of the Lon-like protease MtaLonC in complex with bortezomib

Structural highlights

4fwd is a 1 chain structure with sequence from Meiothermus taiwanensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.03Å
Ligands:BO2, PO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

C9DRU9_9DEIN

Publication Abstract from PubMed

The Lon proteases are a unique family of chambered proteases with a built-in AAA+ (ATPases associated with diverse cellular activities) module. Here, crystal structures of a unique member of the Lon family with no intrinsic ATPase activity in the proteolytically active form are reported both alone and in complexes with three covalent inhibitors: two peptidomimetics and one derived from a natural product. This work reveals the unique architectural features of an ATP-independent Lon that selectively degrades unfolded protein substrates. Importantly, these results provide mechanistic insights into the recognition of inhibitors and polypeptide substrates within the conserved proteolytic chamber, which may aid the development of specific Lon-protease inhibitors.

Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors.,Liao JH, Ihara K, Kuo CI, Huang KF, Wakatsuki S, Wu SH, Chang CI Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1395-402. doi:, 10.1107/S0907444913008214. Epub 2013 Jul 13. PMID:23897463[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
0 reviews cite this structure
Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease.
Su et al. (2016)
-1 more
10 other articles
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References

  1. ↑ Liao JH, Ihara K, Kuo CI, Huang KF, Wakatsuki S, Wu SH, Chang CI. Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1395-402. doi:, 10.1107/S0907444913008214. Epub 2013 Jul 13. PMID:23897463 doi:10.1107/S0907444913008214

Contents


PDB ID 4fwd

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