4hf0

Structural highlights

Function

ISCR_ECOLI Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA.^{[1] [2] [3]}

References

1. ↑ Schwartz CJ, Giel JL, Patschkowski T, Luther C, Ruzicka FJ, Beinert H, Kiley PJ. IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14895-900. Epub 2001 Dec 11. PMID:11742080 doi:10.1073/pnas.251550898
2. ↑ Yeo WS, Lee JH, Lee KC, Roe JH. IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe-S assembly proteins. Mol Microbiol. 2006 Jul;61(1):206-18. PMID:16824106 doi:10.1111/j.1365-2958.2006.05220.x
3. ↑ Otsuka Y, Miki K, Koga M, Katayama N, Morimoto W, Takahashi Y, Yonesaki T. IscR regulates RNase LS activity by repressing rnlA transcription. Genetics. 2010 Jul;185(3):823-30. doi: 10.1534/genetics.110.114462. Epub 2010 Apr, 26. PMID:20421606 doi:10.1534/genetics.110.114462