4ok2

From Proteopedia

Jump to: navigation, search

Crystal Structure of Alg17c Mutant Y258A

Structural highlights

4ok2 is a 2 chain structure with sequence from Saccharophagus degradans 2-40. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.45Å
Ligands:ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EALGL_SACD2 Catalyzes the depolymerization of alginate through an exolytic mode of action, via a beta-elimination mechanism. Preferentially acts on oligoalginates with degrees of polymerization higher than 2 to produce the alginate monomer, 4-deoxy-L-erythro-5-hexoseulose uronic acid.[1] [2]

References

  1. ↑ Kim HT, Chung JH, Wang D, Lee J, Woo HC, Choi IG, Kim KH. Depolymerization of alginate into a monomeric sugar acid using Alg17C, an exo-oligoalginate lyase cloned from Saccharophagus degradans 2-40. Appl Microbiol Biotechnol. 2012 Mar;93(5):2233-9. doi: 10.1007/s00253-012-3882-x. , Epub 2012 Jan 27. PMID:22281843 doi:http://dx.doi.org/10.1007/s00253-012-3882-x
  2. ↑ Park D, Jagtap S, Nair SK. Structure of a PL17 Family Alginate Lyase Demonstrates Functional Similarities among Exotype Depolymerases. J Biol Chem. 2014 Mar 21;289(12):8645-55. doi: 10.1074/jbc.M113.531111. Epub 2014, Jan 29. PMID:24478312 doi:http://dx.doi.org/10.1074/jbc.M113.531111

Contents


PDB ID 4ok2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/4ok2"
Personal tools