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From Proteopedia
Structure of the hazelnut allergen, Cor a 8
Structural highlights
FunctionNLTP_CORAV Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.[RuleBase:RU000628] Publication Abstract from PubMedNonspecific lipid transfer proteins (nsLTPs) are basic proteins, stabilized by four disulfide bonds, and are expressed throughout the plant kingdom. These proteins are also known as important allergens in fruits and tree nuts. In this study, the nsLTP from hazelnuts, Cor a 8, was purified and its crystal structure determined. The protein is stable at low pH and refolds after thermal denaturation. Molecular dynamics simulations were used to provide an insight into conformational changes of Cor a 8 upon ligand binding. When known epitope areas from Pru p 3 were compared to those of Cor a 8, differences were obvious, which may contribute to limited cross-reactivity between peach and hazelnut allergens. Differences in epitope regions may contribute to limited cross-reactivity between Cor a 8 and nsLTPs from other plant sources. The structure of Cor a 8 represents the first resolved structure of a hazelnut allergen. Structural and Functional Characterization of the Hazelnut Allergen Cor a 8.,Offermann LR, Bublin M, Perdue ML, Pfeifer S, Dubiela P, Borowski T, Chruszcz M, Hoffmann-Sommergruber K J Agric Food Chem. 2015 Oct 7. PMID:26417906[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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