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Publication Abstract from PubMed

The natural production of the beta-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance function has been derived.

1.8 A resolution crystal structure of the carbapenem intrinsic resistance protein CarF.,Tichy EM, Hardwick SW, Luisi BF, Salmond GPC Acta Crystallogr D Struct Biol. 2017 Jul 1;73(Pt 7):549-556. doi:, 10.1107/S2059798317002236. Epub 2017 Jun 22. PMID:28695855^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.