Structural highlights
Function
PDS5B_HUMAN Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.[1] [2] [3]
References
- ↑ Geck P, Maffini MV, Szelei J, Sonnenschein C, Soto AM. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10185-90. PMID:10963680
- ↑ Losada A, Yokochi T, Hirano T. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. J Cell Sci. 2005 May 15;118(Pt 10):2133-41. Epub 2005 Apr 26. PMID:15855230 doi:http://dx.doi.org/10.1242/jcs.02355
- ↑ Shintomi K, Hirano T. Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Genes Dev. 2009 Sep 15;23(18):2224-36. doi: 10.1101/gad.1844309. Epub 2009 Aug, 20. PMID:19696148 doi:10.1101/gad.1844309
