Structural highlights
Function
TOPK_HUMAN Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.[1] [2]
References
- ↑ Abe Y, Matsumoto S, Kito K, Ueda N. Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. J Biol Chem. 2000 Jul 14;275(28):21525-31. PMID:10781613 doi:http://dx.doi.org/10.1074/jbc.M909629199
- ↑ Nandi AK, Ford T, Fleksher D, Neuman B, Rapoport AP. Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53. Biochem Biophys Res Commun. 2007 Jun 22;358(1):181-8. Epub 2007 Apr 30. PMID:17482142 doi:http://dx.doi.org/S0006-291X(07)00824-8
