Structural highlights
5mwu is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.8Å |
| Ligands: | , , , , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
NIKA_ECOLI Involved in a nickel transport system, probably represents the nickel binder.
Publication Abstract from PubMed
Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced alpha-hydroxy-beta-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h-1).
Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme.,Lopez S, Rondot L, Cavazza C, Iannello M, Boeri-Erba E, Burzlaff N, Strinitz F, Jorge-Robin A, Marchi-Delapierre C, Menage S Chem Commun (Camb). 2017 Mar 23;53(25):3579-3582. doi: 10.1039/c6cc08873b. PMID:28289745[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Lopez S, Rondot L, Cavazza C, Iannello M, Boeri-Erba E, Burzlaff N, Strinitz F, Jorge-Robin A, Marchi-Delapierre C, Menage S. Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme. Chem Commun (Camb). 2017 Mar 23;53(25):3579-3582. doi: 10.1039/c6cc08873b. PMID:28289745 doi:http://dx.doi.org/10.1039/c6cc08873b
