Structural highlights
Function
TRI23_HUMAN Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.[1]
See Also
References
- ↑ Vichi A, Payne DM, Pacheco-Rodriguez G, Moss J, Vaughan M. E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1945-50. Epub 2005 Jan 31. PMID:15684077 doi:http://dx.doi.org/10.1073/pnas.0409800102