Structural highlights
Function
CARME_HUMAN N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).[1]
References
- ↑ Drozak J, Piecuch M, Poleszak O, Kozlowski P, Chrobok L, Baelde HJ, de Heer E. UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase. J Biol Chem. 2015 Jul 10;290(28):17190-205. doi: 10.1074/jbc.M115.640037. Epub, 2015 May 22. PMID:26001783 doi:http://dx.doi.org/10.1074/jbc.M115.640037
