5z8y

From Proteopedia

Crystal structure of human LRRTM2 in complex with Neurexin 1beta

PDB ID 5z8y

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Structural highlights

5z8y is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.4Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

NRX1B_HUMAN Pitt-Hopkins-like syndrome;Autism;Schizophrenia.

Function

NRX1B_HUMAN Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).

Publication Abstract from PubMed

Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Neurexins (Nrxns) and heparan sulfate proteoglycans have been identified as presynaptic ligands for LRRTMs. Specifically, LRRTM1 and LRRTM2 bind to the Nrxn splice variant lacking an insert at the splice site 4 (S4). Here, we report the crystal structure of the Nrxn1beta-LRRTM2 complex at 3.4 A resolution. The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated interactions and overlaps with the Nrxn-neuroligin interface. Together with structure-based mutational analyses at the molecular and cellular levels, the present structural analysis unveils the mechanism of selective binding between Nrxn and LRRTM1/2 and its modulation by the S4 insertion of Nrxn.

Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.,Yamagata A, Goto-Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, Saitoh T, Maenaka K, Terada T, Yoshida T, Uemura T, Fukai S Nat Commun. 2018 Sep 27;9(1):3964. doi: 10.1038/s41467-018-06333-8. PMID:30262834^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Yamagata A, Goto-Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, Saitoh T, Maenaka K, Terada T, Yoshida T, Uemura T, Fukai S. Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction. Nat Commun. 2018 Sep 27;9(1):3964. doi: 10.1038/s41467-018-06333-8. PMID:30262834 doi:http://dx.doi.org/10.1038/s41467-018-06333-8