5zbg
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proteopedia linkproteopedia linkCryo-EM structure of human TRPC3 at 4.36A resolution
Structural highlights
DiseaseTRPC3_HUMAN The disease is caused by mutations affecting the gene represented in this entry. FunctionTRPC3_HUMAN Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.[1] [2] [3] [4] References
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Categories: Homo sapiens | Large Structures | Chen L | Guo W | Tang Q