6e7b
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proteopedia linkproteopedia link13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules
Structural highlights
DiseaseTBB3_HUMAN Congenital fibrosis of extraocular muscles;Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. FunctionTBB3_HUMAN Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.[1] See AlsoReferences
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