Argonaute

From Proteopedia

Jump to: navigation, search

X-ray structure of the entire human Argonaute2 protein complex with RNA (red) (PDB 4ola) at 2.3Å resolution

External Resources

Uniprot: Q9UKV8

Wikipedia: Piwi Proteins

Wikipedia: Argonaute Proteins

Animation showing the function of Argonaute during RNA interference

References

  1. 1.0 1.1 1.2 Schirle NT, Macrae IJ. The Crystal Structure of Human Argonaute2. Science. 2012 Apr 26. PMID:22539551 doi:10.1126/science.1221551
  2. Hock J, Meister G. The Argonaute protein family. Genome Biol. 2008;9(2):210. Epub 2008 Feb 26. PMID:18304383 doi:10.1186/gb-2008-9-2-210
  3. Ma JB, Ye K, Patel DJ. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature. 2004 May 20;429(6989):318-22. PMID:15152257 doi:10.1038/nature02519
  4. Gu S, Jin L, Huang Y, Zhang F, Kay MA. Slicing-Independent RISC Activation Requires the Argonaute PAZ Domain. Curr Biol. 2012 Aug 21;22(16):1536-42. Epub 2012 Jul 12. PMID:22795694 doi:10.1016/j.cub.2012.06.040
  5. Lingel A, Simon B, Izaurralde E, Sattler M. Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature. 2003 Nov 27;426(6965):465-9. Epub 2003 Nov 16. PMID:14615801 doi:10.1038/nature02123
  6. Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol. 2005 Apr;12(4):340-9. Epub 2005 Mar 30. PMID:15800637 doi:10.1038/nsmb918
  7. Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science. 2004 Sep 3;305(5689):1434-7. Epub 2004 Jul 29. PMID:15284453 doi:10.1126/science.1102514

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, João Rodrigues, Joel L. Sussman, Alexander Berchansky

Personal tools