Beta secretase

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Human β-secretase (PDB code 1w51)


References

  • Alzheimer's Disease: Unraveling the Mystery. US Department of Health and Human Services, National Institute on Aging, NIH. 2008.
  • CambridgeJournals. <http://journals.cambridge.org/fulltext_content/EPH/EPH87_04/S0958067001024046g003.htm>
  • Patel S, Vuillard L, Cleasby A, Murray CW, Yon J (2004). "Apo and Inhibitor Complex Structures of BACE (β-secretase)". J.Mol.Biol. 343:407.
  • Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999). "β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE". Science 286:735-741.
  • Willem M, Dewachter I, Smyth N, Dooren TV, Borghgraef P, Haass C, Leuven FV (2004). "β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE x APP[V717I] Double-Transgenic Mice". The American Journal of Pathology 165:1621-1631.
  • Wilquet V, Strooper BD (2004). "Amyloid-beta Precursor Protein Processing in Neurodegeneration". Current Opinion in Neurobiology 14:582-588.
  • Xu, Y., Li, M., Greenblatt, H.M., Chen, W., Paz, A., Dym, O., Peleg, Y., Chen, T., Shen, X., He, J., Jiang, H., Silman, I. & Sussman, J.L. (2012). “Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations” Acta Crystallogr D Biol Crystallogr D68, 13-25.

See also

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