Function
Bromodomain-containing proteins (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones[1].
For detalis on BRD3 see Human bromodomain containing protein 3
Disease
Dysfunction of BRD is involved in cancer, inflammation, obesity and multiple sclerosis[2]. BRD4 translocations are detected in NUT midline carcinoma and a variety of BRD4 inhibitors are clinically tested at the present[3].
Structural highlights
[4]. Water molecules are shown as red spheres.
3D Structures of bromodomain-containing protein
Bromodomain-containing protein 3D structures
