Function
BtuBor vitamin B12 receptor or outer membrane cobalamin transporter is an outer membrane receptor found in a variety of bacteria, such as E. coli. BtuB transports vitamin B12 across the membrane of gram-negative bacteria. The transport is achieved with high affinity by the collaboration of BtuB and the periplasmic protein TonB. [1] As an essential receptor for the cell that is constitutively expressed, it is an ideal target to be parasitized, a feature exploited by a variety of proteins such as Colicins.
Structural highlights
BtuB depends on the presence of Ca+2 ions for high affinity . The .[2]
3D structure of BtuB
BtuB 3D structures
