CD47

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Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions 2jjs

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3D Structures of CD47

Updated on 16-November-2022

7ygg – hCD47 extracellular domain + SIRP α - human
2jjs, 2jjt, 4kjy – hCD47 extracellular domain (mutant) + SIRP α
2vsc – hCD47 extracellular domain (mutant)
4cmm - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate
5iwl – hCD47 extracellular domain (mutant) + 5F9 diabody
5tz2, 5tzt, 5tzu – hCD47 extracellular domain (mutant) + antibody
7myz – hCD47 extracellular domain/cytochrome b562 + antibody

References

  1. Chao MP, Weissman IL, Majeti R. The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications. Curr Opin Immunol. 2012 Apr;24(2):225-32. doi: 10.1016/j.coi.2012.01.010. Epub, 2012 Feb 4. PMID:22310103 doi:http://dx.doi.org/10.1016/j.coi.2012.01.010
  2. Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508 doi:10.1016/j.molcel.2008.05.026

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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