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Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry 3b9k)


  1. Devine L, Sun J, Barr MR, Kavathas PB. Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J Immunol. 1999 Jan 15;162(2):846-51. PMID:9916707
  2. Shore DA, Issafras H, Landais E, Teyton L, Wilson IA. The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I. J Mol Biol. 2008 Dec 31;384(5):1190-202. Epub 2008 Oct 7. PMID:18929574 doi:10.1016/j.jmb.2008.09.069

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Alexander Berchansky, Michal Harel

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