CYP3A4

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Human heme-containing cytochrome P450 3A4 complex with inhibitor (PDB code 4ny4)

References

  1. Ogu CC, Maxa JL. Drug interactions due to cytochrome P450. Proc (Bayl Univ Med Cent). 2000 Oct;13(4):421-3. PMID:16389357
  2. Gonzalez FJ. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat Res. 2005 Jan 6;569(1-2):101-10. PMID:15603755 doi:http://dx.doi.org/10.1016/j.mrfmmm.2004.04.021
  3. Meunier B, de Visser SP, Shaik S. Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes. Chem Rev. 2004 Sep;104(9):3947-80. PMID:15352783 doi:http://dx.doi.org/10.1021/cr020443g
  4. Meunier B, de Visser SP, Shaik S. Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes. Chem Rev. 2004 Sep;104(9):3947-80. PMID:15352783 doi:http://dx.doi.org/10.1021/cr020443g
  5. Devlin, Thomas M., ed. Textbook of Biochemistry with Clinical Correlations. 6th ed. Hoboken: John Wiley, 2006. Print.
  6. Inoue K, Inazawa J, Nakagawa H, Shimada T, Yamazaki H, Guengerich FP, Abe T. Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization. Jpn J Hum Genet. 1992 Jun;37(2):133-8. PMID:1391968 doi:http://dx.doi.org/10.1007/BF01899734
  7. Dai D, Tang J, Rose R, Hodgson E, Bienstock RJ, Mohrenweiser HW, Goldstein JA. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther. 2001 Dec;299(3):825-31. PMID:11714865
  8. Dai D, Tang J, Rose R, Hodgson E, Bienstock RJ, Mohrenweiser HW, Goldstein JA. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther. 2001 Dec;299(3):825-31. PMID:11714865
  9. PMCID: PMC2045626

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