Function
Calcineurin (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways.
For more details see Group:MUZIC:Calcineurin.
Relevance
CN inhibitors are used as drugs in cases of rheumatic diseases, schizophrenia and diabetes. It is inhibited by immunosuppressant drugs like cyclosporine.
Structural highlights
It contains a and a . There are (molecules of water are shown as red spheres).[1]
3D structures of calcineurin
Calcineurin 3D structures
