Calreticulin

From Proteopedia

Human calreticulin (gold) complex with β-microglobulin (green), tapasin (pink), protein disulfide-isomerase (yellow) MHC class I antigen (cyan) (PDB code 6eny) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights 5 3D Structures of calreticulin Function Calreticulin (CALR) is a multifunction calcium-binding chaperone. CALR is a molecular chaperone, an extracellular lectin, an intracellular mediator of integrin function, an inhibitor of steroid hormone-regulated gene expression and a C1q-binding protein[1]. Disease Most patients with essential thrombocythemia or primary myelofibrosis not associated with JAK2 or MPL mutation have CALR mutation[2]. Relevance CALR is active in regulating intracellular Ca+2 homeostasis[3]. Structural highlights : N-terminal globular domain which has chaperone function; P-domain which is proline-rich, binds Ca+2 with high affinity and possesses a lectin-like chaperone function; C-terminal domain containing an ER retention signal. 3D Structures of calreticulin Calreticulin 3D structures

References

1. ↑ Coppolino MG, Dedhar S. Calreticulin. Int J Biochem Cell Biol. 1998 May;30(5):553-8. PMID:9693955
2. ↑ Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD, Them NC, Berg T, Gisslinger B, Pietra D, Chen D, Vladimer GI, Bagienski K, Milanesi C, Casetti IC, Sant'Antonio E, Ferretti V, Elena C, Schischlik F, Cleary C, Six M, Schalling M, Schonegger A, Bock C, Malcovati L, Pascutto C, Superti-Furga G, Cazzola M, Kralovics R. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013 Dec 19;369(25):2379-90. doi: 10.1056/NEJMoa1311347. Epub 2013 , Dec 10. PMID:24325356 doi:http://dx.doi.org/10.1056/NEJMoa1311347
3. ↑ Wang WA, Groenendyk J, Michalak M. Calreticulin signaling in health and disease. Int J Biochem Cell Biol. 2012 Jun;44(6):842-6. doi: 10.1016/j.biocel.2012.02.009., Epub 2012 Feb 21. PMID:22373697 doi:http://dx.doi.org/10.1016/j.biocel.2012.02.009