Catalytic Subunit of T. Castaneum TERT Polymerase

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Telomerase reverse transcriptase complex with DNA, RNA and Mg+2 (green) ion (PDB code 3kyl).

3D structures of TERT polymerase

Telomerase

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Mitchell M, Gillis A, Futahashi M, Fujiwara H, Skordalakes E. Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nat Struct Mol Biol. 2010 Apr;17(4):513-8. Epub 2010 Mar 28. PMID:20357774 doi:10.1038/nsmb.1777
  2. Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 2012 Aug;4(8):691-704. doi: 10.1002/emmm.201200245. Epub 2012 May, 15. PMID:22585399 doi:10.1002/emmm.201200245
  3. European Journal of Cancer, Volume 33, Issue 5, April 1997, Pages 787–791 http://dx.doi.org/10.1016/S0959-8049(97)00062-2
  4. FEBS Letters, Volume 579, Issue 4, 7 February 2005, Pages 859–862 http://dx.doi.org/10.1016/j.febslet.2004.11.036

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