Collagen

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Structure of Collagen (PDB entry 4clg or 1cag)

 
Gly Packing in 4clg ()
Ala Packing in 1cag (Mutated Collagen) ()


In order to convince yourself that there is a difference in the interchain distances in the area of the Ala, between Gly (Ala) and Pro which form intratropocollagen hydrogen bonds. Hydrogen bonds are not formed between Ala and Pro because the distances between the atoms forming the bonds are too great. The absence of the intratropocollagen hydrogen bonds, which is due to replacing Gly with a residue having a longer side chain, disrupts collagen's rope-like structure and is responsible for the symptoms of such human diseases as osteogenesis imperfecta and certain Ehlers-Danlos syndromes.

Contents

3D structures of collagen

Updated on 20-November-2014


References

  1. J.M. Chen, C.E. Kung, S.H. Feairheller, E.M. Brown, AN ENERGETIC EVALUATION OF A "SMITH" COLLAGEN MICROFIBRIL MODEL, J. Protein Chem., 10, 535, 1991
  2. J.BELLA,M.EATON,B.BRODSKY,H.M.BERMAN, CRYSTAL AND MOLECULAR STRUCTURE OF A COLLAGEN-LIKE PEPTIDE AT 1.9 A RESOLUTION. SCIENCE, 266, 75, 1994

External Links

Movies of assembly of triple helix of type I and IV collagen.

Contributor

Much of the content of this page was taken from an earlier non-Proteopedia version of Collagen which was in large part developed by Gretchen Heide Bisbort, a 1999 graduate of Messiah College.

Proteopedia Page Contributors and Editors (what is this?)

Karl Oberholser, Alexander Berchansky, Michal Harel, Ala Jelani, Jaime Prilusky, Eric Martz, Eran Hodis, David Canner, Judy Voet, Tilman Schirmer

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