In order to convince yourself that there is a difference in the interchain distances in the area of the Ala, between Gly (Ala) and Pro which form intratropocollagen hydrogen bonds. Hydrogen bonds are not formed between Ala and Pro because the distances between the atoms forming the bonds are too great. The absence of the intratropocollagen hydrogen bonds, which is due to replacing Gly with a residue having a longer side chain, disrupts collagen's rope-like structure and is responsible for the symptoms of such human diseases as osteogenesis imperfecta and certain Ehlers-Danlos syndromes.
3D structures of collagen
Updated on 20-November-2014
Movies of assembly of triple helix of type I and IV collagen.
Much of the content of this page was taken from an earlier non-Proteopedia version of Collagen which was in large part developed by Gretchen Heide Bisbort, a 1999 graduate of Messiah College.