Complement factor

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Structure of human complement factor H 19-20 sushi domains (magenta) complex with complement C3 (green) and glycerol (PDB code 3oxu).

Drag the structure with the mouse to rotate

References

  1. Rodriguez de Cordoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sanchez-Corral P. The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol. 2004 Jun;41(4):355-67. PMID:15163532 doi:10.1016/j.molimm.2004.02.005
  2. Narni-Mancinelli E, Gauthier L, Baratin M, Guia S, Fenis A, Deghmane AE, Rossi B, Fourquet P, Escaliere B, Kerdiles YM, Ugolini S, Taha MK, Vivier E. Complement factor P is a ligand for the natural killer cell-activating receptor NKp46. Sci Immunol. 2017 Apr 28;2(10). doi: 10.1126/sciimmunol.aam9628. PMID:28480349 doi:http://dx.doi.org/10.1126/sciimmunol.aam9628
  3. Stanton CM, Yates JR, den Hollander AI, Seddon JM, Swaroop A, Stambolian D, Fauser S, Hoyng C, Yu Y, Atsuhiro K, Branham K, Othman M, Chen W, Kortvely E, Chalmers K, Hayward C, Moore AT, Dhillon B, Ueffing M, Wright AF. Complement factor D in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8828-34. doi: 10.1167/iovs.11-7933. PMID:22003108 doi:http://dx.doi.org/10.1167/iovs.11-7933
  4. Alexander P, Gibson J, Cree AJ, Ennis S, Lotery AJ. Complement factor I and age-related macular degeneration. Mol Vis. 2014 Sep 13;20:1253-7. eCollection 2014. PMID:25352734
  5. Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Proce S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ. Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome. Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09242. doi:, 10.1161/HYPERTENSIONAHA.117.09242. PMID:28739975 doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09242

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