Corticosteroid-binding globulin

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Cartoon representation of corticosteroid-binding globulin complex with cortisol, 2v95

3D structures of corticosteroid-binding protein

Updated on 19-October-2017

2v95 – rSer-A6 – rat
2vdx, 4c41 – hSer-A6 (mutant) - human
2vdy, 4c49 – hSer-A6 (mutant) + cortisol‬
4bb2 – hSer-A6 (mutant) + progesterone

Resources

Nucleotide and amino acid sequence [1]

PDB structure of S-state rat CBG [2]

PDB structure of R-state human CBG-antitrypsin chimera [3]

PDB structure of R-state human CBG-antitrypsin chimera [4]

References

  1. WESTPHAL U. Steroid-protein interactions. III. Spectrophotometric demonstration of interaction between proteins and progesterone, deoxycorticosterone and cortisol. Arch Biochem Biophys. 1957 Jan;66(1):71-90. PMID:13395526
  2. Mickelson KE, Harding GB, Forsthoefel M, Westphal U. Steroid-protein interactions. Human corticosteroid-binding globulin: characterization of dimer and electrophoretic variants. Biochemistry. 1982 Feb 16;21(4):654-60. PMID:7074030
  3. Pemberton PA, Stein PE, Pepys MB, Potter JM, Carrell RW. Hormone binding globulins undergo serpin conformational change in inflammation. Nature. 1988 Nov 17;336(6196):257-8. PMID:3143075 doi:http://dx.doi.org/10.1038/336257a0
  4. WESTPHAL U. Steroid-protein interactions. III. Spectrophotometric demonstration of interaction between proteins and progesterone, deoxycorticosterone and cortisol. Arch Biochem Biophys. 1957 Jan;66(1):71-90. PMID:13395526
  5. Mickelson KE, Harding GB, Forsthoefel M, Westphal U. Steroid-protein interactions. Human corticosteroid-binding globulin: characterization of dimer and electrophoretic variants. Biochemistry. 1982 Feb 16;21(4):654-60. PMID:7074030
  6. Klieber MA, Underhill C, Hammond GL, Muller YA. Corticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered release. J Biol Chem. 2007 Oct 5;282(40):29594-603. Epub 2007 Jul 19. PMID:17644521 doi:10.1074/jbc.M705014200
  7. Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RW. The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J Mol Biol. 2008 Jun 27;380(1):244-51. Epub 2008 May 14. PMID:18513745 doi:10.1016/j.jmb.2008.05.012
  8. Windle RJ, Wood SA, Lightman SL, Ingram CD. The pulsatile characteristics of hypothalamo-pituitary-adrenal activity in female Lewis and Fischer 344 rats and its relationship to differential stress responses. Endocrinology. 1998 Oct;139(10):4044-52. PMID:9751481
  9. Pemberton PA, Stein PE, Pepys MB, Potter JM, Carrell RW. Hormone binding globulins undergo serpin conformational change in inflammation. Nature. 1988 Nov 17;336(6196):257-8. PMID:3143075 doi:http://dx.doi.org/10.1038/336257a0
  10. Torpy DJ, Ho JT. Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders. Clin Endocrinol (Oxf). 2007 Aug;67(2):161-7. Epub 2007 Jun 4. PMID:17547679 doi:10.1111/j.1365-2265.2007.02890.x
  11. Lin HY, Muller YA, Hammond GL. Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol. 2010 Mar 5;316(1):3-12. Epub 2009 Jul 28. PMID:19643161 doi:10.1016/j.mce.2009.06.015
  12. Klieber MA, Underhill C, Hammond GL, Muller YA. Corticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered release. J Biol Chem. 2007 Oct 5;282(40):29594-603. Epub 2007 Jul 19. PMID:17644521 doi:10.1074/jbc.M705014200
  13. Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RW. The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J Mol Biol. 2008 Jun 27;380(1):244-51. Epub 2008 May 14. PMID:18513745 doi:10.1016/j.jmb.2008.05.012
  14. Klieber MA, Underhill C, Hammond GL, Muller YA. Corticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered release. J Biol Chem. 2007 Oct 5;282(40):29594-603. Epub 2007 Jul 19. PMID:17644521 doi:10.1074/jbc.M705014200
  15. Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RW. The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J Mol Biol. 2008 Jun 27;380(1):244-51. Epub 2008 May 14. PMID:18513745 doi:10.1016/j.jmb.2008.05.012
  16. Pemberton PA, Stein PE, Pepys MB, Potter JM, Carrell RW. Hormone binding globulins undergo serpin conformational change in inflammation. Nature. 1988 Nov 17;336(6196):257-8. PMID:3143075 doi:http://dx.doi.org/10.1038/336257a0
  17. Fernandez-Real JM, Grasa M, Casamitjana R, Pugeat M, Barret C, Ricart W. Plasma total and glycosylated corticosteroid-binding globulin levels are associated with insulin secretion. J Clin Endocrinol Metab. 1999 Sep;84(9):3192-6. PMID:10487686
  18. Teves ME, Guidobaldi HA, Unates DR, Sanchez R, Miska W, Giojalas LC. Progesterone sperm chemoattraction may be modulated by its corticosteroid-binding globulin carrier protein. Fertil Steril. 2010 May 1;93(7):2450-2. Epub 2009 Nov 6. PMID:19896663 doi:10.1016/j.fertnstert.2009.09.012
  19. Torpy DJ, Ho JT. Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders. Clin Endocrinol (Oxf). 2007 Aug;67(2):161-7. Epub 2007 Jun 4. PMID:17547679 doi:10.1111/j.1365-2265.2007.02890.x
  20. Lin HY, Muller YA, Hammond GL. Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol. 2010 Mar 5;316(1):3-12. Epub 2009 Jul 28. PMID:19643161 doi:10.1016/j.mce.2009.06.015

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