Cyclin-dependent kinase

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CDK2 (cyan) complex with cyclin A2 (green), ATP analog roscovitine and monothioglycerol (PDB code 3ddq)

References

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  2. Liu P, Kao TP, Huang H. CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor. Oncogene. 2008 Aug 7;27(34):4733-44. doi: 10.1038/onc.2008.104. Epub 2008 Apr 14. PMID:18408765 doi:http://dx.doi.org/10.1038/onc.2008.104
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  8. Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol. 2010 Feb;17(2):194-201. doi: 10.1038/nsmb.1752. Epub 2010, Jan 24. PMID:20098423 doi:http://dx.doi.org/10.1038/nsmb.1752
  9. Dubbury SJ, Boutz PL, Sharp PA. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Nature. 2018 Dec;564(7734):141-145. doi: 10.1038/s41586-018-0758-y. Epub 2018 Nov, 28. PMID:30487607 doi:http://dx.doi.org/10.1038/s41586-018-0758-y
  10. Greenleaf AL. Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium. Transcription. 2019 Apr;10(2):91-110. doi: 10.1080/21541264.2018.1535211. Epub, 2018 Oct 22. PMID:30319007 doi:http://dx.doi.org/10.1080/21541264.2018.1535211
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