Cytochrome P450 hydroxylase

From Proteopedia

Cytochrome P450 hydroxylase containing heme complex with lauric acid, sulfate and glycerol (PDB code 5cwe) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Cytochrome P450 hydroxylase (CPH) acts in the in-chain hydroxylation of lauric acid which is required for the development of the male organ in higher plants[1]. CPH hydroxylyzes the anti-cholesterol natural product herbosidiene[2]. See also Cytochrome P450 and Hemeproteins. . . . in Cytochrome P450 hydroxylase from Steptomyces avermitilis (PDB code 5cwe). 3D Structures of cytochrome P450 hydroxylase Cytochrome P450 hydroxylase 3D structures

References

1. ↑ Yang X, Wu D, Shi J, He Y, Pinot F, Grausem B, Yin C, Zhu L, Chen M, Luo Z, Liang W, Zhang D. Rice CYP703A3, a cytochrome P450 hydroxylase, is essential for development of anther cuticle and pollen exine. J Integr Plant Biol. 2014 Oct;56(10):979-94. doi: 10.1111/jipb.12212. Epub 2014, Jul 15. PMID:24798002 doi:http://dx.doi.org/10.1111/jipb.12212
2. ↑ Yu D, Xu F, Shao L, Zhan J. A specific cytochrome P450 hydroxylase in herboxidiene biosynthesis. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4511-4514. doi:, 10.1016/j.bmcl.2014.07.078. Epub 2014 Aug 6. PMID:25139567 doi:http://dx.doi.org/10.1016/j.bmcl.2014.07.078