Function
Diacylglycerol kinase (DAGK) catalyzes the conversion of diacylglycerol to phosphaditic acid using ATP as energy source. DAGK is active upon receptor activation of the phosphoinositide pathway.[1] The bacterial DAGK contains 2 families: DgkA and DgkB.
Relevance
DAGK is tested as a possible therapeutic target for neuronal diseases.
Structural highlights
In DAGK DgkB the is found at the interface between the 2 domains of the structure. [2] Water molrcules are shown asred spheres.
3D Structures of diacylglycerol kinase
Diacylglycerol kinase 3D structures
