Directed evolution

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References

  • Rothlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Kemp elimination catalysts by computational enzyme design. Nature. 2008 May 8;453(7192):190-5. Epub 2008 Mar 19. PMID:18354394 doi:10.1038/nature06879
  • Levin KB, Dym O, Albeck S, Magdassi S, Keeble AH, Kleanthous C, Tawfik DS. Following evolutionary paths to protein-protein interactions with high affinity and selectivity. Nat Struct Mol Biol. 2009 Oct;16(10):1049-55. Epub 2009 Sep 13. PMID:19749752 doi:10.1038/nsmb.1670
  • Khersonsky O, Rothlisberger D, Dym O, Albeck S, Jackson CJ, Baker D, Tawfik DS. Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series. J Mol Biol. 2010 Mar 5;396(4):1025-42. Epub 2009 Dec 28. PMID:20036254 doi:10.1016/j.jmb.2009.12.031

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Alexander Berchansky

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