Function
Estrogen-related receptor (ERR) binds to estrogen response elements on DNA and modulates transcription in response to hormone. It is a nuclear receptor. There are 3 classes of ERR : ERRα, ERRβ and ERRγ.
See also Intracellular receptors
Relevance
ERR plays a role in energy homeostasis and cancer[1]. ERRα and ERRγ are overexpressed in breast cancer and can serve as prognostic markers or therapeutic targets.
Structural insights
to human estrogen-related receptor γ. The chemotherapeutic drugs bisphenol and are nestled between 4 alpha helices in the ERR active site [2].
3D structures of estrogen-related receptor
Estrogen-related receptor 3D structures