GABA(A) receptor-associated protein

From Proteopedia

Human GABARAP (deep sky blue) complex with LIR peptide (green) (PDB entry 4xc2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Relevance 3 Structural highlights 4 3D Structures of GABA receptor-associated protein Function GABA(A) receptor-associated protein (GABARAP) is associated and promotes the clustering of GABA(A) receptors in fibroids[1]. GABARAP interacts with the γ2 subunit of GABA(A) receptor[2]. GABARAP transports GABA(A) receptors to the plasma membrane of neurons[3]. GABARAP-like 1 (GABARAPL1) is ubiquitin-like and it increases cell-surface expression of κ-type opioid receptor and is involved in the elongation of the phagophore membrane. Relevance GABARAP is an autoantigen in stiff-person syndrome[4]. Structural highlights The [5]. . 3D Structures of GABA receptor-associated protein GABA receptor-associated protein 3D structures

References

1. ↑ Chen L, Wang H, Vicini S, Olsen RW. The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11557-62. doi:, 10.1073/pnas.190133497. PMID:10984509 doi:http://dx.doi.org/10.1073/pnas.190133497
2. ↑ Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature. 1999 Jan 7;397(6714):69-72. PMID:9892355 doi:http://dx.doi.org/10.1038/16264
3. ↑ Leil TA, Chen ZW, Chang CS, Olsen RW. GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neurons. J Neurosci. 2004 Dec 15;24(50):11429-38. doi: 10.1523/JNEUROSCI.3355-04.2004. PMID:15601949 doi:http://dx.doi.org/10.1523/JNEUROSCI.3355-04.2004
4. ↑ Raju R, Rakocevic G, Chen Z, Hoehn G, Semino-Mora C, Shi W, Olsen R, Dalakas MC. Autoimmunity to GABAA-receptor-associated protein in stiff-person syndrome. Brain. 2006 Dec;129(Pt 12):3270-6. doi: 10.1093/brain/awl245. Epub 2006 Sep 19. PMID:16984900 doi:http://dx.doi.org/10.1093/brain/awl245
5. ↑ Genau HM, Huber J, Baschieri F, Akutsu M, Dotsch V, Farhan H, Rogov V, Behrends C. CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling. Mol Cell. 2015 Feb 11. pii: S1097-2765(14)01018-1. doi:, 10.1016/j.molcel.2014.12.040. PMID:25684205 doi:http://dx.doi.org/10.1016/j.molcel.2014.12.040