Glycated hemoglobin

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Glycated Hemoglobin is a form of hemoglobin with sugars attached to certain amino acid side chains. When blood sugar levels in an individual are high for long periods of time (hyperglycemia) as is the case for people with diabetes) when blood sugar is not managed, these sugar modifications accumulate. The so-called HbA1c test[1] is used as a measure of hyperglycemia over the past ~3 months. The time span of 3 months corresponds roughly to the average time red blood cells remain in the blood stream. When they are replenished by fresh cells, these carry hemoglobin that does not yet have the modification [2].

Structure

Glycated hemoglobin (PDB ID 5hy8)

References

  1. Yonehara S, Inamura N, Fukuda M, Sugiyama K. Use of fructosyl peptide oxidase for HbA1c assay. J Diabetes Sci Technol. 2015 Mar;9(2):200-5. doi: 10.1177/1932296815569573. Epub , 2015 Jan 28. PMID:25633966 doi:http://dx.doi.org/10.1177/1932296815569573
  2. https://pdb101.rcsb.org/global-health/diabetes-mellitus/monitoring/diagnosis?more=y
  3. https://en.wikipedia.org/wiki/Amadori_rearrangement
  4. https://www.cdc.gov/nchs/data/nhanes/nhanes_07_08/GHB_E_met_Tosoh_22_Plus.pdf

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Karsten Theis

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