HIV-1 Reverse Transcriptase in Complex with Nevirapine

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Crystal Structure of HIV-1 Reverse Transcriptase with DNA and the nonnucleoside inhibitor nevirapine (PDB entry 3v81)

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References

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  2. Steitz, Thomas A. DNA Polymerases: Structural Diversity and Common Mechanisms. Jour. Bio. Chem. 274:17395-17398 (1999). DOI:10.1074/jbc.274.25.17395
  3. 3.0 3.1 3.2 Sluis-Cremer N, Temiz NA, Bahar I. Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding. Curr HIV Res. 2004 Oct;2(4):323-32. PMID:15544453
  4. 4.0 4.1 4.2 Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science. 1992 Jun 26;256(5065):1783-90. PMID:1377403 doi:[http://dx.doi.org/10.1126/science.1377403 http://dx.doi.org/10.1126/science.1377403
  5. U.S.F.&D. Administration. http://www.fda.gov/ForConsumers/byAudience/ForPatientAdvocates/HIVandAIDSActivities/ucm118915.htm
  6. Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH Jr, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E. Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J Mol Biol. 1996 Dec 20;264(5):1085-100. PMID:9000632
  7. 7.0 7.1 Hsiou Y, Ding J, Das K, Clark AD Jr, Hughes SH, Arnold E. Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure. 1996 Jul 15;4(7):853-60. PMID:8805568
  8. Mui PW, Jacober SP, Hargrave KD, Adams J. Crystal structure of nevirapine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase, and computational alignment with a structurally diverse inhibitor. J Med Chem. 1992 Jan;35(1):201-2. PMID:1370694
  9. 9.0 9.1 9.2 9.3 9.4 Das K, Martinez SE, Bauman JD, Arnold E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat Struct Mol Biol. 2012 Jan 22;19(2):253-9. doi: 10.1038/nsmb.2223. PMID:22266819 doi:10.1038/nsmb.2223
  10. Liu S, Abbondanzieri EA, Rausch JW, Le Grice SF, Zhuang X. Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates. Science. 2008 Nov 14;322(5904):1092-7. PMID:19008444 doi:10.1126/science.1163108

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