Horse Liver Alcohol Dehydrogenase

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Horse liver alcohol dehydrogenase complex with Zn+2 ion (grey) and ribofuranosylpicolinamide adenine dinucleotide (PDB code 1a72)


3D structures of horse liver alcohol dehydrogenase

Alcohol dehydrogenase

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Ramaswamy S, Eklund H, Plapp BV. Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols. Biochemistry. 1994 May 3;33(17):5230-7. PMID:8172897
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Bahnson BJ, Colby TD, Chin JK, Goldstein BM, Klinman JP. A link between protein structure and enzyme catalyzed hydrogen tunneling. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12797-802. PMID:9371755
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Colby TD, Bahnson BJ, Chin JK, Klinman JP, Goldstein BM. Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes. Biochemistry. 1998 Jun 30;37(26):9295-304. PMID:9649310 doi:10.1021/bi973184b
  4. 4.0 4.1 4.2 4.3 4.4 Bahnson BJ, Park DH, Kim K, Plapp BV, Klinman JP. Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis. Biochemistry. 1993 Jun 1;32(21):5503-7. PMID:8504071
  5. 5.0 5.1 5.2 Eklund H, Nordstrom B, Zeppezauer E, Soderlund G, Ohlsson I, Boiwe T, Soderberg BO, Tapia O, Branden CI, Akeson A. Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution. J Mol Biol. 1976 Mar 25;102(1):27-59. PMID:178875
  6. 6.0 6.1 6.2 Brandt EG, Hellgren M, Brinck T, Bergman T, Edholm O. Molecular dynamics study of zinc binding to cysteines in a peptide mimic of the alcohol dehydrogenase structural zinc site. Phys Chem Chem Phys. 2009 Feb 14;11(6):975-83. Epub 2008 Dec 12. PMID:19177216 doi:10.1039/b815482a
  7. Olson LP, Luo J, Almarsson O, Bruice TC. Mechanism of aldehyde oxidation catalyzed by horse liver alcohol dehydrogenase. Biochemistry. 1996 Jul 30;35(30):9782-91. PMID:8703951 doi:10.1021/bi952020x

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