How B-lactam drugs work

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How beta-lactam drugs work

D-alanyl-D-alanine carboxipeptidase transpeptidase complex with cephalothin (PDB code 1ceg)

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References

  1. Tan SY, Tatsumura Y. Alexander Fleming (1881-1955): Discoverer of penicillin. Singapore Med J. 2015 Jul;56(7):366-7. doi: 10.11622/smedj.2015105. PMID:26243971 doi:http://dx.doi.org/10.11622/smedj.2015105
  2. Kuzin AP, Liu H, Kelly JA, Knox JR. Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases. Biochemistry. 1995 Jul 25;34(29):9532-40. PMID:7626623

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