Image:The Normal DDAH Mechanism.jpg
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The normal mechanism of DDAH. This figure highlights the importance of Cys249 acting as the nucleophile that attacks the guanidinium carbon on the substrate that is held in the active site via hydrogen bonds. The tetrahedral product collapses as the alkylamine leaving group leaves. The sp2 thiouronium intermediate is hydrolyzed to form citrulline. His162 protonates the alkylamine leaving group and generates hydroxide to hydrolyze the intermediate formed in the reaction.
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| Date/Time | User | Dimensions | File size | Comment | |
|---|---|---|---|---|---|
| (current) | 00:41, 31 March 2017 | Natalie Van Ochten (Talk | contribs) | 1215×627 | 65 KB | The normal mechanism of DDAH. This figure highlights the importance of Cys249 acting as the nucleophile that attacks the guanidinium carbon on the substrate that is held in the active site via hydrogen bonds. The tetrahedral product collapses as the alkyl |
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