Insulin-like growth factor binding protein

From Proteopedia

Insulin-like growth factor binding protein N terminal (green) complex with Insulin-like growth factor I (wheat) (PDB code 2dsp) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)[1]. The N-terminal of IGFBP is the domain which binds IGF I. Disease IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration[2],[3]. IGFBP-3 level is decreased in patients with inflammatory bowel disease[4]. IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells[5]. IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease[6]. 3D structures of insulin-like growth factor binding protein Insulin-like growth factor binding protein 3D structures

References

1. ↑ Hwa V, Oh Y, Rosenfeld RG. The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev. 1999 Dec;20(6):761-87. PMID:10605625 doi:http://dx.doi.org/10.1210/edrv.20.6.0382
2. ↑ Bach LA, Fu P, Yang Z. Insulin-like growth factor-binding protein-6 and cancer. Clin Sci (Lond). 2013 Feb;124(4):215-29. doi: 10.1042/CS20120343. PMID:23126425 doi:http://dx.doi.org/10.1042/CS20120343
3. ↑ Rocha RL, Hilsenbeck SG, Jackson JG, VanDenBerg CL, Weng Cn, Lee AV, Yee D. Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free survival. Clin Cancer Res. 1997 Jan;3(1):103-9. PMID:9815544
4. ↑ Kirman I, Whelan RL, Jain S, Nielsen SE, Seidelin JB, Nielsen OH. Insulin-like growth factor binding protein 3 in inflammatory bowel disease. Dig Dis Sci. 2005 Apr;50(4):780-4. PMID:15844718
5. ↑ Durai R, Davies M, Yang W, Yang SY, Seifalian A, Goldspink G, Winslet M. Biology of insulin-like growth factor binding protein-4 and its role in cancer (review). Int J Oncol. 2006 Jun;28(6):1317-25. PMID:16685432
6. ↑ Heald AH, Cruickshank JK, Riste LK, Cade JE, Anderson S, Greenhalgh A, Sampayo J, Taylor W, Fraser W, White A, Gibson JM. Close relation of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in two populations. Diabetologia. 2001 Mar;44(3):333-9. PMID:11317665 doi:http://dx.doi.org/10.1007/s001250051623