Insulin receptor

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Insulin Receptor

Insulin Receptor with Four Insulins Bound: (PDB Code 6SOF). Alpha subunits in blue, beta subunits in orange, and 4 insulin molecules bound in green.

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References

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  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Boucher J, Kleinridders A, Kahn CR. Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1). pii: 6/1/a009191. doi:, 10.1101/cshperspect.a009191. PMID:24384568 doi:http://dx.doi.org/10.1101/cshperspect.a009191
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 Uchikawa E, Choi E, Shang G, Yu H, Bai XC. Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife. 2019 Aug 22;8. pii: 48630. doi: 10.7554/eLife.48630. PMID:31436533 doi:http://dx.doi.org/10.7554/eLife.48630
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  5. 5.0 5.1 Schaffer L, Ljungqvist L. Identification of a disulfide bridge connecting the alpha-subunits of the extracellular domain of the insulin receptor. Biochem Biophys Res Commun. 1992 Dec 15;189(2):650-3. PMID:1472036
  6. White MF, Kahn CR. The insulin signaling system. J Biol Chem. 1994 Jan 7;269(1):1-4. PMID:8276779
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  8. Hubbard SR. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J. 1997 Sep 15;16(18):5572-81. PMID:9312016 doi:10.1093/emboj/16.18.5572
  9. Cabail MZ, Li S, Lemmon E, Bowen ME, Hubbard SR, Miller WT. The insulin and IGF1 receptor kinase domains are functional dimers in the activated state. Nat Commun. 2015 Mar 11;6:6406. doi: 10.1038/ncomms7406. PMID:25758790 doi:http://dx.doi.org/10.1038/ncomms7406
  10. 10.0 10.1 Sparrow LG, McKern NM, Gorman JJ, Strike PM, Robinson CP, Bentley JD, Ward CW. The disulfide bonds in the C-terminal domains of the human insulin receptor ectodomain. J Biol Chem. 1997 Nov 21;272(47):29460-7. doi: 10.1074/jbc.272.47.29460. PMID:9368005 doi:http://dx.doi.org/10.1074/jbc.272.47.29460
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  14. Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct, 17. PMID:27760050 doi:http://dx.doi.org/10.1172/JCI86013
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