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(General Description) Interleukin-15 (IL-15) is a 14-15kDa cytokine with similar biological functions to IL-2 (Kirman, 1998), eliciting such responses as differentiation and proliferation of lymphocytes, expression of cytolytic programs in lymphocytic killer cells, and chemoattraction of T cells (Chae, 1996). IL-15 has also been implicated in homeostatic proliferaton and deemed necessary for CD8+ T cell memory. In high enough concentrations, IL-15 has been implicated in chronic inflammatory diseases.

Structure & Function


(Structural Description) (highlighting domains, folds and/or motifs) This is a placeholder text to help you get started in placing a Jmol applet on your page. At any time, click "Show Preview" at the bottom of this page to see how it goes.

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Mouse interleukin-15 complex with interleukin-15 receptor α chain and benzamidine, 2psm
Gene: Il15 (Mus musculus), Il15ra (Mus musculus)
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml

3D structures of interleukin



Proteopedia Page Contributors and Editors (what is this?)

Phan Thai, Michal Harel

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