Interleukin-15/Sandbox

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(General Description) Interleukin-15 (IL-15) is a 14-15kDa cytokine with similar biological functions to IL-2 (Kirman, 1998), eliciting such responses as differentiation and proliferation of lymphocytes, expression of cytolytic programs in lymphocytic killer cells, and chemoattraction of T cells (Chae, 1996). IL-15 has also been implicated in homeostatic proliferaton and deemed necessary for CD8+ T cell memory. In high enough concentrations, IL-15 has been implicated in chronic inflammatory diseases.


Structure & Function

Structure

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Mouse interleukin-15 complex with interleukin-15 receptor α chain and benzamidine, 2psm
Ligands:
Gene: Il15 (Mus musculus), Il15ra (Mus musculus)
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml



3D structures of interleukin

Interleukin

Image:IL15-IL15Ra.png


Proteopedia Page Contributors and Editors (what is this?)

Phan Thai, Michal Harel

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