Interleukin receptor antagonist

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Human interleukin-1 receptor antagonist dimer, 1ilr

3D structures of IL1RA

2irt, 1ilr, 1ilt – hIL1RA – human
1irp - hIL1RA – NMR
1ira - hIL1RA + interleukin-1 receptor extracellular domain
4p0j, 4p0k, 4p0l – hIL36RA/IL36 γ (mutant)

References

  1. Arend WP, Malyak M, Guthridge CJ, Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 1998;16:27-55. PMID:9597123 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.27
  2. Mertens M, Singh JA. Anakinra for rheumatoid arthritis. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD005121. doi:, 10.1002/14651858.CD005121.pub3. PMID:19160248 doi:http://dx.doi.org/10.1002/14651858.CD005121.pub3
  3. Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, Zribi J, Bal E, Cluzeau C, Chrabieh M, Towne JE, Douangpanya J, Pons C, Mansour S, Serre V, Makni H, Mahfoudh N, Fakhfakh F, Bodemer C, Feingold J, Hadj-Rabia S, Favre M, Genin E, Sahbatou M, Munnich A, Casanova JL, Sims JE, Turki H, Bachelez H, Smahi A. Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med. 2011 Aug 18;365(7):620-8. doi: 10.1056/NEJMoa1013068. PMID:21848462 doi:http://dx.doi.org/10.1056/NEJMoa1013068

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