Function
Kelch-like proteins (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. . β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions[1].
- KLHL2 KLHL11 is a component of the cullin-RING based E3 ubiquitin-protein ligase system.
- KLHL3 and KLHL7 KLHL10 are substrate-specific adapters of the cullin-RING based E3 ubiquitin-protein ligase system.
- KLHL12 may play a role in collagen export.
- KLHL16 or gigaxonin plays a role in neurofilament architecture.
- KLHL19 (Keap1) interacts with the Neh2 peptide of NRF2.
Disease
Somatic mutations in Keap1 were found in lung cancer patients.
Relevance
NRF2 is a regulator of antioxidant response, hence Keap1 is investigated as a drug target.
Structural highlights
The [2]. . Water molecules shown as red spheres.
3D Structures of Kelch-like protein
Kelch-like protein 3D structures
