Ku protein

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Structure of the Ku heterodimer bound to DNA (PDB entry 1jey)

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3D Structures of Ku protein

Updated on 14-October-2021

1jey, 5y58 – hKu70 + Ku80 + DNA – human
1jeq – hKu70 + Ku80
7axz – hKu70 + Ku80 – Cryo EM
6zh6 – hKu80 + DNA-dependent protein kinase – Cryo EM
7k0y, 7k1j, 7k1k, 7k1n – hKu70 + Ku80 + DNA-dependent protein kinase – Cryo EM
6erf, 6erg, 6erh – hKu70 + Ku80 + non-homologous end-joining factor + DNA
1jjr – hKu70 C terminal - NMR
1rw2, 1q2z – hKu80 C terminal - NMR
6tyt, 6tyu, 6tyv, 6tyw, 6tyx, 6tyz – hKu80 von Willebrand domain 1-242 (mutant) + peptide
7lt3 – hKu70 + Ku80 in NHEJ synaptic complex – Cryo EM

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Walker JR, Corpina RA, Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature. 2001 Aug 9;412(6847):607-14. PMID:11493912 doi:10.1038/35088000
  2. Bennett SM, Neher TM, Shatilla A, Turchi JJ. Molecular analysis of Ku redox regulation. BMC Mol Biol. 2009 Aug 28;10:86. doi: 10.1186/1471-2199-10-86. PMID:19715578 doi:http://dx.doi.org/10.1186/1471-2199-10-86
  3. 3.0 3.1 3.2 Polotnianka RM, Li J, Lustig AJ. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr Biol. 1998 Jul 2;8(14):831-4. PMID:9663392
  4. 4.0 4.1 Bertuch AA, Lundblad V. The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. Mol Cell Biol. 2003 Nov;23(22):8202-15. PMID:14585978
  5. Berg, Jeremy M., John L. Tymoczko, and Lubert Stryer. Biochemistry. 7th ed. New York: W.H. Freeman and, 2012. ISBN-10: 1-4292-2936-5

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