Lamprey Variable Lymphocyte Receptor

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Lamprey Variable Lymphocyte Receptor in complex with a protein antigen (3g3a)
Lamprey Variable Lymphocyte Receptor in complex with a protein antigen (3g3a)

Lamprey Variable Lymphocyte Receptor in complex with a trisaccharide antigen (3e6j), resolution 1.67Å ()
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

Crystal Structure of Variable Lymphocyte Receptor (VLR) RBC36 in Complex with H-trisaccharide

About these Structures

Lamprey VLRs are members of the Leucine-rich repeat (LRR) family of diverse proteins. Variable lymphocyte receptors are involved in the adaptative immune response.
3e6j is a single chain structure of sequence from Petromyzon marinus. Full crystallographic information is available from OCA.

3g3b is an 8 chain structure with sequences from Gallus gallus and Petromyzon marinus. Full crystallographic information is available from OCA.

3g3a is an 8 chain structure with sequences from Gallus gallus and Petromyzon marinus. Full crystallographic information is available from OCA.

3g39 is a single chain structure with sequence from Petromyzon marinus. Full crystallographic information is available from OCA.

3m18 is a 2 chain structure with sequences from Gallus gallus and Petromyzon marinus. Full crystallographic information is available from OCA.

3m19 is a 2 chains structure with sequences from Petromyzon marinus. Full crystallographic information is available from OCA.

3D structures of variable lymphocyte receptor

Variable lymphocyte receptor

References and Notes

  • Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834
  • Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
  • Deng L, Velikovsky CA, Xu G, Iyer LM, Tasumi S, Kerzic MC, Flajnik MF, Aravind L, Pancer Z, Mariuzza RA. A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey. Proc Natl Acad Sci U S A. 2010 Jul 8. PMID:20616002

See Also

Additional Literature

  • Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
  • Pancer Z, Amemiya CT, Ehrhardt GR, Ceitlin J, Gartland GL, Cooper MD. Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature. 2004 Jul 8;430(6996):174-80. PMID:15241406 doi:10.1038/nature02740
  • Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200
  • Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
  • Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  • Liang J, Liu X, Wu FF, Li QW. [Progress of adaptive immunity system of agnathan vertebrates] Yi Chuan. 2009 Oct;31(10):969-76. PMID:19840917


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