MDM4

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Human MDM4 p53-binding domain (grey) complex peptide inhibitor (green) and K+ ion (purple) (PDB entry 3izo)

3D Structures of MDM4

Updated on 19-July-2017

2cr8 – hMDM4 ZF-RNBP domain – NMR
3dab, 2mwy – hMDM4 SWIB domain + p53 transactivation domain
2n06, 2n0u, 2n0w, 2n14 – hMDM4 SWIB domain + p53 transactivation domain – NMR
3fdo, 3jzo, 3jzp, 3jzq, 4rxz – hMDM4 SWIB domain + peptide
3fe7, 3fea, 3eqy - hMDM4 SWIB domain (mutant) + peptide
3lbj, 3u15 - hMDM4 SWIB domain + inhibitor
3dac – hMDM4 SWIB domain (mutant) + p53 transactivation domain
2vyr – hMDM4 SWIB domain + antibody
2vje, 2vjf – hMDM2 residues 383-446 + hMDM4 residues 428-490
5mnj – hMDM4 SWIB domain + hMDM2 residues 428-491 + polyubiquitin + ubiquitin-conjugating enzyme E2
2z5s - zMDM4 SWIB domain + p53 transactivation domain – zebrafish
2z5t - zMDM4 SWIB domain (mutant) + p53 transactivation domain
4n5t - zMDM4 SWIB domain (mutant) + stapled peptide

References

  1. Migliorini D, Lazzerini Denchi E, Danovi D, Jochemsen A, Capillo M, Gobbi A, Helin K, Pelicci PG, Marine JC. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol. 2002 Aug;22(15):5527-38. PMID:12101245
  2. Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, Shi H, Moriceau G, Lo RS, Ghanem G, Shackleton M, Bernal F, Marine JC. MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med. 2012 Aug;18(8):1239-47. doi: 10.1038/nm.2863. Epub 2012 Jul 22. PMID:22820643 doi:http://dx.doi.org/10.1038/nm.2863

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