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Methyl CpG Binding Protein 2
This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University.
Additional Structures of MeCP2
MeCP2 is present in mature nerve cells and is involved in turning off several genes. Human MeCP2 are called MBD1 to MBD4 and contain a methyl-CpG binding domain (MBD) which binds to methylated DNA.
1ig4 – hMBD1 MBD domain + DNA – human – NMR
1d9n - hMBD1 MBD domain – NMR
3iho – hMBD4 glycosylate domain
1qk9 - hMeCP2 MBD domain - NMR
3c2i – hMeCP2 MBD domain (mutant) + DNA
1ub1 – MeCP2 attachment-region binding domain – chicken – NMR
1ngn - MBD4 glycosylate domain - mouse
- ↑ 1.0 1.1 1.2 1.3 Ho KL, McNae IW, Schmiedeberg L, Klose RJ, Bird AP, Walkinshaw MD. MeCP2 binding to DNA depends upon hydration at methyl-CpG. Mol Cell. 2008 Feb 29;29(4):525-31. PMID:18313390 doi:10.1016/j.molcel.2007.12.028
- ↑ Zoghbi HY. Postnatal neurodevelopmental disorders: meeting at the synapse? Science. 2003 Oct 31;302(5646):826-30. PMID:14593168 doi:10.1126/science.1089071
- ↑ Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12;143(4):527-39. PMID:21074045 doi:10.1016/j.cell.2010.10.016
- ↑ Guy J, Gan J, Selfridge J, Cobb S, Bird A. Reversal of neurological defects in a mouse model of Rett syndrome. Science. 2007 Feb 23;315(5815):1143-7. Epub 2007 Feb 8. PMID:17289941 doi:10.1126/science.1138389