Molecular Playground/CLOCK:BMAL1 heterodimer complex

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CLOCK:BMAL1 heterodimer complex

mouse CLOCK:BMAL1 heterodimer complex (PDB code 4f3l).

References

  1. http://dx.doi.org/10.1126/science.280.5369.1564
  2. Silver R, Kriegsfeld LJ. Circadian rhythms have broad implications for understanding brain and behavior. Eur J Neurosci. 2014 Jun;39(11):1866-80. doi: 10.1111/ejn.12593. Epub 2014 May 5. PMID:24799154 doi:http://dx.doi.org/10.1111/ejn.12593
  3. Huang N, Chelliah Y, Shan Y, Taylor CA, Yoo SH, Partch C, Green CB, Zhang H, Takahashi JS. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 2012 Jul 13;337(6091):189-94. Epub 2012 May 31. PMID:22653727 doi:10.1126/science.1222804
  4. Lowrey PL, Takahashi JS. Genetics of circadian rhythms in Mammalian model organisms. Adv Genet. 2011;74:175-230. doi: 10.1016/B978-0-12-387690-4.00006-4. PMID:21924978 doi:http://dx.doi.org/10.1016/B978-0-12-387690-4.00006-4
  5. http://dx.doi.org/http
  6. http://dx.doi.org/10.1097/01.ede.0000152525.21924.54
  7. Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai S, Bass J. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009 May 1;324(5927):651-4. doi: 10.1126/science.1171641. Epub 2009 Mar , 19. PMID:19299583 doi:http://dx.doi.org/10.1126/science.1171641

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