Monoclonal Antibody

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Mouse monoclonal antibody matuzumab light chain (aqua) and heavy chain (red) complex with sulfate (PDB code 3c08)

3D structure of monoclonal antibody

3D structures of monoclonal antibody

References

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  2. Roit, I. M. Roit's Essential Immunology. Oxford: Blackwell Science Ltd., 1997.
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  14. Bagshawe KD. Antibody-directed enzyme prodrug therapy (ADEPT) for cancer. Expert Rev Anticancer Ther. 2006 Oct;6(10):1421-31. PMID:17069527 doi:10.1586/14737140.6.10.1421
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  16. http://www.nanotech-now.com/news.cgi?story_id=38872
  17. Lippow SM, Wittrup KD, Tidor B. Computational design of antibody-affinity improvement beyond in vivo maturation. Nat Biotechnol. 2007 Oct;25(10):1171-6. Epub 2007 Sep 23. PMID:17891135 doi:10.1038/nbt1336
  18. Gribenko AV, Patel MM, Liu J, McCallum SA, Wang C, Makhatadze GI. Rational stabilization of enzymes by computational redesign of surface charge-charge interactions. Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:19196981
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